The phrase “to pursue them” refers to

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                              Don’t Think Your Success Is A Matter of Luck

Richard Hamming argues a major roadblock is thinking your success will be mainly about luck. To do first rate work, you have to drop any modesty and say to yourself: “Yes, I would like to do something significant.” Pasteur said, “Luck favors the prepared mind.” The prepared mind will eventually find something important and then do it. One characteristic of great people is usually “when they were young they had independent thoughts and had the courage to pursue them.” He says: “Once you get your courage up and believe that you can do important problems, then you can.”                                                                                                 Psychology Today Magazine